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Nathanael Mathew

Don’t Let the Pressure Get to You: Decompression Sickness

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Don’t Let the Pressure Get to You: Decompression Sickness

It is hard to imagine that making bubbles could be anything more than a fun and innocent childhood activity. When you think of bubbles, the first thing to pop into your mind may be a line of kids running across a field with bottles of soapy water, outstretched arms, and laughter. Yet, in a much different context (i.e. the vacuum of space), making bubbles is a dangerous process that can occur in the body and can lead to a condition known as decompression sickness.

Before learning about decompression sickness (DCS) in outer space, let us view it in a more familiar context here on Earth: scuba diving. As a scuba diver descends further and further below the surface of the water, the pressure rises around them[1]. This increase in pressure occurs because the deeper one goes, the “more” water is on top of them. It turns out that as pressure increases, the scuba diver breathes in more air molecules than they typically do because high pressures cause the air to be compressed. The additional oxygen from this extra air can be used by the body, but the additional nitrogen molecules in the air accumulate in the body [2]. The high pressure essentially allows for the nitrogen molecules to become dissolved, but that changes when the scuba diver returns to the surface [3]. As the diver ascends and the pressure decreases, the nitrogen will try to escape their body, and whatever is not expired ends up turning into nitrogen bubbles inside the body [2],[3].These bubbles are dangerous, as they can cause inflammation that leads to pain in muscles/joints and even obstruct blood vessels [2]. In the case of a diver experiencing DCS, one treatment option is hyperbaric oxygen therapy through a hyperbaric chamber. Essentially, in this treatment option, the affected person will sit in a chamber at a high initial pressure and the pressure will gradually decrease (allowing the nitrogen to freely exit the body rather than forming bubbles) [1].

The effects of DCS are not merely restricted to diving. Space is a very low-pressure environment, so special concerns related to DCS must be taken into account by astronauts. The pressure of the International Space Station (ISS) is 14.7 psi, which is about the same atmospheric pressure experienced at sea level on Earth. So if an astronaut has to exit the ISS in order to participate in extravehicular activity, there would be a drop in pressure [4]. To counteract the negative effects this may have, prior to leaving for their spacewalk, astronauts undergo a special breathing regimen consisting of 100% oxygen [4]. This prevents nitrogen gas from forming bubbles in the body since, hypothetically, there would be no nitrogen gas in the body. Such a measure is important as it helps prevent astronauts from having to experience DCS in space.

Pressure really can affect the body extensively, especially in the context of DCS. Thankfully, there are methods and interventions to help prevent and alleviate issues arising from it. So, the next time you see children playing with bubbles, don’t forget how bubbles can turn out to be harmful to the body. You can pass on telling them about it though; they’re probably not in any high pressure stakes at the moment. 

References

  1. Healthwise staff. U of M Health. https://www.uofmhealth.org/health-library/abo0894 (accessed February 2022).

  2. Moon, Richard E. Merck Manual Consumer Version. https://www.merckmanuals.com/home/injuries-and-poisoning/diving-and-compressed-air-injuries/decompression-sickness (accessed February 2022)

  3. Cooper, Jeffrey S.; Hanson, Kenneth C. Decompression Sickness. In StatPearls; StatPearls Publishing; Treasure Island (FL), updated 2021. https://www.ncbi.nlm.nih.gov/books/NBK537264/ (accessed February 2022)

  4. Canadian Space Agency. https://www.asc-csa.gc.ca/eng/astronauts/space-medicine/decomp.asp (accessed February 2022)

  5. NASA-Imagery / 29 images. Pixabay. https://pixabay.com/photos/space-walk-astronaut-nasa-aerospace-991/ (accessed February 2022)

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Attacking Cancer: A Golden Opportunity

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Attacking Cancer: A Golden Opportunity

You don’t have to be a historian to grasp the significant impact gold has made in the world. From a sought-out treasure to a method of currency, there’s no doubt that this element is one of the most influential metals in human history. Yet, a much less known aspect of gold is its incredible potential in biomedicine. This is especially true of gold nanoparticles in the context of cancer.


Cancer is a condition wherein cells proliferate and divide in an uncontrolled manner. [1] While cancer can often be treated, the side effects of those treatments can be severe and can include possibly hurting non-cancer cells and the immune system. Inducing hyperthermia, or causing a part of the body to heat up, has been shown to have an anticancer potential as it can lead to programmed cell death as well as make tumors more susceptible to radiotherapy. Yet, a central issue arises: unless the heat is localized, other parts of the body can be harmed. This is where gold nanoparticles come in. [2]


In the simplest terms, gold nanoparticles are small pieces of gold. Very small pieces of gold. As a result, gold nanoparticles have a lot of different properties compared to, say, a block of gold that we often think about when talking about the element. For instance, gold nanoparticles are not yellow: particles less than 100 nm are red while bigger particles are blue/purple. [3] These nanoparticles have amazing properties which allow them to act as a contrast in CT scans or assist with drug delivery. [4] Yet, one of the most fascinating applications of these gold nanoparticles is their use in photothermal therapy. Because the blood vessels near the tumor site are often leaky, gold nanoparticles that have been placed in a cancer patient's body will passively concentrate near a tumor. Once they have concentrated, they can be activated by near-infrared light, a special type of light which can easily pass through human tissues. The gold nanoparticles will absorb the light energy and convert it to heat energy near the tumor, essentially stimulating the cancer cells’ deaths. [2]


Has this technique been tested in humans? In fact, yes–a clinical trial done at Mt. Sinai hospital which used gold-silica nanoparticles to treat prostate cancer patients revealed no severe side effects from the treatment. After the gold nanoparticles had concentrated at the tumor site of the patients, they were irradiated by near-infrared light from optical fibers. These nanoparticles absorbed the light and heated the tumor site, essentially destroying it. [5]


The promise of such a localized treatment strategy is encouraging. Hopefully, further research can be done to explore this opportunity that is, indeed, worth its weight in gold.


References

[1] Gupta, N.; Malviya, R. Understanding and advancement in gold nanoparticle targeted photothermal therapy of cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer [Online] 2021. 1875, 188532. https://www.sciencedirect.com/science/article/pii/S0304419X21000305?via%3Dihub (accessed November 2021)

[2] Vines, J.B.; Yoon, J.-H.; Ryu, N.-E.; Lim, D.-J.; Park, H. Gold nanoparticles for photothermal cancer therapy. Front. Chem. [Online] 2019. 7, 167. https://www.frontiersin.org/articles/10.3389/fchem.2019.00167/full (accessed November 2021) 

[3] Sztandera, K.; Gorzkiewicz, M.; Klajnert-Maculewicz, B. Gold Nanoparticles in Cancer Treatment. Mol. Pharmaceutics [Online] 2019. 16, 1-23. https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00810 (accessed November 2021)

[4] Wang, S.; Lu, G. Noble and Precious Metals - Properties, Nanoscale Effects and Applications. In Applications of gold nanoparticles in cancer imaging and treatment; Intechopen: Online, 2017.

[5] Stephens, M. PhysicsWorld. https://physicsworld.com/a/gold-nanoshell-based-cancer-treatment-is-safe-for-the-clinic/ (accessed November 2021)

[6] Pxfuel. https://p1.pxfuel.com/preview/830/131/627/cancer-cells-cells-scan-electron-microscope-scan.jpg (accessed November 2021)

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